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目的 探讨人类重组粒细胞集落刺激因子 (rhG CSF)对抗甲状腺药物所致白细胞减少症的疗效。方法 对我院 1996～ 2 0 0 1年收治的 3 2例抗甲状腺药物所致的白细胞减少症患者 ,采用常规升白细胞治疗 (对照组 )和rhG CSF治疗 (治疗组 ) ,观察两组疗效。结果 rhG CSF具有明显促进白细胞恢复的疗效 ,其时间长短与白细胞下降的程度有关。对Ⅲ度和Ⅳ度白细胞减少者有效率显著高于对照组。结论 rhG CSF是治疗抗甲状腺药物所致白细胞减少症的安全、快速、有效的药物
Objective To investigate the effect of human recombinant granulocyte-colony stimulating factor (rhG CSF) on anti-thyroid drug induced leukopenia. Methods Thirty two cases of leucopenia caused by antithyroid drugs in our hospital from 1996 to 2001 were treated with routine leukocyte (control group) and rhG CSF (treatment group), and the curative effect of the two groups were observed. The results rhG CSF has a significant effect of promoting leukocyte recovery, the duration of leukopenia and its extent. The third and fourth degree of leukopenia were significantly higher than the efficiency of the control group. Conclusion rhG CSF is a safe, rapid and effective anti-thyroid drug for the treatment of leukopenia