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目的描述四川省2007～2008年急性弛缓性麻痹(Acute Flaccid Paralysis,AFP)病例监测中,分离到的部分非脊髓灰质炎肠道病毒(Nonpolio Enterovirus,NPEV)的型别特征,探讨AFP病例可能的病原谱。方法对四川省2007～2008年AFP病例中分离到的14株NPEV进行基因测序定型。结果测序结果经比较分析,确定肠道病毒(Enterovirus,EV)A组的柯萨奇病毒A组4、5、10型(Coxsackievirus Group A Type4、5、10,CVA4、CVA5、CVA10)和EV71型(Type71,EV71)各1株;EVB组的埃柯病毒(Enteric Cytopathogenic Human Orphan Virus,ECHO;引起细胞病变的人肠道孤儿病毒)6型(ECHO6)和30型(ECHO30)各3株,ECHO251株,CVA91株,CVB3和CVB5各1株。结论四川省2007～2008年AFP病例的病原谱可能包括多型别的NPEV。
Objective To describe the types of nonpolio enterovirus (NPEV) isolated in the surveillance of Acute Flaccid Paralysis (AFP) cases in Sichuan Province from 2007 to 2008 and to explore the possible features of AFP cases Pathogen spectrum. Methods Fourteen NPEV isolates from 2007 to 2008 in Sichuan Province were genotyped and sequenced. Results The sequencing results were compared to determine the Coxsackievirus Group A Type 4,5,10 (CVA4, CVA5, CVA10) and EV71 type of Enterovirus (EV) (Type71, EV71); 3 strains of ECHO6 and 30 (ECHO30) of Enteric Cytopathogenic Human Orphan Virus (ECHO; cytopathogenic human enterovirus); 6 strains of ECHO251 One strain of CVA91, one each of CVB3 and CVB5. Conclusions The pathogenic profiles of AFP cases in Sichuan Province from 2007 to 2008 may include multiple types of NPEV.