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目的 观察降纤酶对治疗急性脑梗死的实验室指标和临床功能的影响。方法 采用前瞻性、双盲、随机、对照的方法 ,对 90例发病在 2 4小时之内的急性脑梗死患者进行了实验室与临床观察。结果 降纤酶对血纤维蛋白原有明显的降低作用 (P <0 0 1) ,对凝血酶原时间和肝、肾功能无影响 ,对神经功能恢复有明显作用 (P <0 0 1) ,但与对照组比较两组无统计学意义 (P >0 0 5 )。结论 降纤酶有明显的降低血纤维蛋白原作用 ,并且无明显的副作用 ,有促进神经功能恢复的作用 ,但与常规治疗无显著差异 ;降纤酶是一种安全有效的药物。
Objective To observe the effect of defibrase on the laboratory indexes and clinical functions in the treatment of acute cerebral infarction. Methods A prospective, double-blind, randomized, controlled trial was performed in 90 patients with acute cerebral infarction within 24 hours. Results Defibrase had a significant reduction in fibrinogen (P <0.01), had no effect on prothrombin time and liver and kidney function, and had a significant effect on nerve function recovery (P <0.01) However, compared with the control group, there was no significant difference between the two groups (P> 0.05). Conclusion defibrase has a significant role in reducing fibrinogen, and no significant side effects, promote neurological recovery, but no significant difference with the conventional treatment; defibrase is a safe and effective drug.