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目的:探讨心率变异对原发性高血压患者预后的影响。方法:选择126例高血压患者,分为正常组、异常组及福辛普利药物治疗组,患者均随访1年,观察患者1年心脑血管事件发生率及其余基本生命体征情况,统计学对比。结果:患者分别于治疗后6个月、1年进行跟踪随访,三组患者常规治疗用药并无明显区别,福辛普利组用药后SNDD为(87.2±10.1)ms,正常组(117.5±14.9)ms,两组对比有统计学差异。福辛普利组用药后HR为(67.9±9.5)次/min,正常组(173.2±8.9)次/min,两组对比有统计学差异。结论:HRV异常的原发性高血压患者可能预示动脉硬化进展加快,HRV成为判断原发性高血压患者预后的指标之一。福辛普利可干预HRV异常,改善原发性高血压患者的预后。
Objective: To investigate the effect of heart rate variability on the prognosis of patients with essential hypertension. Methods: A total of 126 hypertensive patients were selected and divided into normal group, abnormal group and fosinopril drug treatment group. The patients were followed up for 1 year. The incidence of cardiovascular events and other basic vital signs in one year were observed. Statistics Compared. Results: The patients were followed up for 6 months and 1 year respectively. There was no significant difference between the three groups in the conventional treatment. The SNDD in the fosinopril group was (87.2 ± 10.1) ms, and in the normal group (117.5 ± 14.9) ) ms, the two groups were statistically significant differences. Fosinopril group after treatment of HR was (67.9 ± 9.5) times / min, normal group (173.2 ± 8.9) / min, the two groups were statistically significant differences. CONCLUSIONS: Patients with essential hypertension with abnormal HRV may indicate accelerated progression of arteriosclerosis, and HRV may be one of the prognostic indicators in patients with essential hypertension. Fosinopril can interfere with abnormal HRV and improve the prognosis of patients with essential hypertension.