目的探讨女性泌尿生殖道感染患者中支原体的感染状况及其对不同药物的敏感性,为临床合理用药提供参考。方法对516例女性泌尿生殖道拭子进行支原体培养,并对阳性菌株进行10种常用抗生素药敏试验。结果 516例患者中,支原体培养阳性263例,检出率为50.97%,其中解脲支原体(Ureaplasma urealyticum,UU)为237例(45.93%),人型支原体(Mycoplasma hominis,MH)仅9例(1.74%),UU+MH 17例(6.46%);三种类型感染均对交沙霉素、强力霉素、美满霉素比较敏感。结论 UU为沈阳医学院附属第二医院泌尿生殖道支原体感染的主要病原体,交沙霉素、强力霉素及美满霉素可作为治疗的经验用药,其中交沙霉素为首选抗生素。 Objective To investigate the infection status of mycoplasma in female patients with genitourinary tract infection and its sensitivity to different drugs so as to provide a reference for clinical rational drug use. Methods Mycoplasma culture was performed on 516 female genitourinary swabs, and ten common antibiotic susceptibility tests were performed on the positive strains. Results Of the 516 patients, 263 were positive for mycoplasma, with a detection rate of 50.97%. Ureaplasma urealyticum (UU) was 237 (45.93%) and mycoplasma hominis (MH) only 9 1.74%), UU + MH 17 cases (6.46%); all three types of infections are more sensitive to jasminemycin, doxycycline, minocycline. Conclusion UU is the main causative agent of genitourinary tract mycoplasma infection in the Second Affiliated Hospital of Shenyang Medical College. Jurisstamycin, doxycycline and minocycline can be used as empirical therapeutic drugs, of which josamycin is the first choice antibiotic.