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目的 研究肺癌患者血浆可溶性Ｐ选择素（ｓｏｌｕｂｌｅ Ｐｓｅｌｅｃｔｉｎ ，ｓＰｓｅｌ） 的水平并探讨其临床意义。方法 采用ＥＬＩＳＡ法检测了８４ 例不同期别的肺癌患者血浆中ｓＰｓｅｌ 含量。结果 各期肺癌患者血浆中ｓＰｓｅｌ 含量均明显高于正常对照组（ Ｐ ＜０ ．０１） ；小细胞性肺癌中广泛型患者血浆ｓＰｓｅｌ 的含量显著高于局限型（ Ｐ＜ ０ ．０１） ；非小细胞性肺癌患者中Ⅳ期与Ⅲ期患者ｓＰｓｅｌ的含量显著高于Ⅱ期、且Ⅳ期高于Ⅲ期（ Ｐ＜ ０ ．０１） 。结论 ｓＰｓｅｌ 水平与肺癌的发生及发展有一定关系，且随病情的恶化ｓＰｓｅｌ 的含量显著增高。因此，检测血浆ｓＰｓｅｌ 对肺癌的发生、发展机理的研究及对病情的判断有一定的参考价值。
Objective To study the plasma level of soluble P-selectin (sPsel) in patients with lung cancer and to explore its clinical significance. Methods The plasma levels of sPsel in 84 patients with different stages of lung cancer were detected by ELISA. Results The levels of sPsel in plasma of patients with lung cancer at various stages were significantly higher than those in normal controls (P <0.01). The plasma levels of sPsel in patients with small cell lung cancer were significantly higher than those in patients with localized lung cancer (P <0.01). 01). The content of sPsel in stage Ⅳ and stage Ⅲ patients with non-small cell lung cancer was significantly higher than that in stage Ⅱ, and stage Ⅳ was higher than stage Ⅲ (P0.01). Conclusion sP selenium levels and the occurrence and development of lung cancer have a certain relationship, and with the deterioration of the condition sP sesel content was significantly higher. Therefore, the detection of plasma sP sel on the occurrence and development of lung cancer research and judgment of the disease have some reference value.