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目的了解白血病患儿医院感染易感因素。方法收集我院１０年来收治的白血病患儿１６５例进行分析。结果８６例发生医院感染，感染率为５２．１％，感染率与患儿白细胞总数、病情恶化程度及住院时间有明显关系，病原体多为革兰氏阴性菌，其次为金黄色葡萄球菌、念珠菌和少数条件致病菌。结论疾病本身和化疗导致的免疫抑制和骨髓抑制为医院感染的主要原因之一。长期住院亦增加了感染机会并导致感染率增高
Objective To understand the susceptibility factors of nosocomial infection in children with leukemia. Methods Totally 165 children with leukemia who were treated in our hospital for 10 years were collected for analysis. Results 86 cases of nosocomial infection, the infection rate was 52.1%, the infection rate and the total number of children with leukocytosis, the severity of the disease and hospital stay were significantly related to pathogens, mostly Gram-negative bacteria, followed by Staphylococcus aureus, rosary Bacteria and a few opportunistic pathogens. Conclusions The disease itself and chemotherapy-induced immunosuppression and myelosuppression are one of the major causes of nosocomial infections. Long-term hospitalization also increases the chances of infection and leads to an increased infection rate