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目的：研究苦参碱（Ｍａｔ）对纤维蛋白纤维蛋白原降解产物（ＦＦＤＰ）作用的影响。方法：大鼠主动脉内皮细胞损伤以乳酸脱氢酶释放测定；大鼠主动脉平滑肌细胞增殖采用结晶紫染色法测定；白细胞介素１活性采用小鼠胸腺细胞增殖法测定。结果：ＦＦＤＰ能促进大鼠主动脉内皮细胞释放乳酸脱氢酶，诱导大鼠主动脉平滑肌细胞增殖，并促使小鼠腹腔巨噬细胞分泌ＩＬ１增加。结论：Ｍａｔ可抑制ＦＦＤＰ的作用。对动脉粥样硬化的防治可能有一定意义。
Objective: To study the effect of matrine on fibrin fibrinogen degradation products (FFDP). METHODS: Rat aortic endothelial cell injury was measured by lactate dehydrogenase release; rat aortic smooth muscle cell proliferation was measured by crystal violet staining; interleukin1 activity was measured by mouse thymocyte proliferation assay. RESULTS: FFDP promoted the release of lactate dehydrogenase from rat aortic endothelial cells, induced the proliferation of rat aortic smooth muscle cells, and promoted the secretion of IL-1 from mouse peritoneal macrophages. Conclusion: Mat can inhibit the effect of FFDP. The prevention and treatment of atherosclerosis may have some significance.