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目的:探讨不同抗血小板方案对缺血性脑血管病(ICVD)患者行数字减影血管造影技术(DSA)检查相关并发症的影响。方法:将2013年4月至2016年5月在东莞市黄江医院确诊为ICVD并行DSA的62例病患按随机数字表法,分为观察组和对照组各31例。对照组给予阿司匹林(ASP),观察组给予ASP联合氯吡格雷,记录并对比两组患者DSA前、DSA后7 d血小板聚集情况及DSA检查相关并发症的发生情况。结果:DSA检查前,两组患者血小板聚集率比较,差异均无统计学意义(P>0.05);DSA检查后7 d,两组血小板聚集率较同组均明显降低,差异具有统计学意义(P<0.05),其中观察组患者血小板聚集率较对照组下降幅度更明显,差异具有统计学意义(P<0.05)。同时采用不同的抗血小板方案后,两组患者行DSA检查相关并发症发生情况比较,差异无统计学意义(P>0.05)。结论:ASP联合氯吡格雷虽然不能显著改善患者行DSA相关并发症的发生情况,但对血小板聚集的抑制作用明显优于单用ASP,能有效降低血栓风险,减少因DSA检查造成的血栓现象。
Objective: To investigate the effect of different antiplatelet regimens on complications associated with digital subtraction angiography (DSA) in patients with ischemic cerebrovascular disease (ICVD). Methods: From April 2013 to May 2016, 62 patients diagnosed as ICVD concurrent DSA in Huangjiang Hospital of Dongguan City were randomly divided into observation group and control group with 31 cases in each group. The control group was given aspirin (ASP). The observation group was treated with ASP combined with clopidogrel. The incidence of platelet aggregation and DSA-related complications before and after DSA were recorded and compared between the two groups. Results: Before DSA, there was no significant difference in platelet aggregation between the two groups (P> 0.05). On the 7th day after DSA, the platelet aggregation rate in both groups was significantly lower than that in the same group (P <0.05) P <0.05). The decrease rate of platelet aggregation in the observation group was more significant than that in the control group (P <0.05). At the same time using different anti-platelet program, the two groups of patients with DSA-related complications comparisons, the difference was not statistically significant (P> 0.05). Conclusion: ASP combined with clopidogrel can not significantly improve the incidence of DSA-related complications in patients, but its inhibitory effect on platelet aggregation is better than that of single ASP, which can effectively reduce the risk of thrombosis and reduce the thrombus caused by DSA.