论文部分内容阅读
目的本试验通过已建立的ScN2a细胞模型,探讨阿魏酸对朊病毒复制的影响。方法通过Western blot法检测阿魏酸对朊病毒复制作用的影响。结果 0.5、1和5μg/mL的阿魏酸能够极显著的抑制PrPSc的表达水平(P<0.01)。结论由于中药单体阿魏酸可以抑制ScN2a中PrPSc蛋白的复制,所以中药单体阿魏酸对朊病毒病可能起到一定的治疗作用,这为我们以后对于研究朊病毒的治疗提供了新的思路。
Objective In this study, we examined the effect of ferulic acid on prion replication through established ScN2a cell model. Methods Western blot was used to detect the effect of ferulic acid on prion replication. Results Ferulic acid at 0.5, 1 and 5 μg / mL could significantly inhibit the expression of PrPSc (P <0.01). Conclusion As the Chinese medicine monomer ferulic acid can inhibit the replication of PrPSc protein in ScN2a, the Chinese medicine monomer ferulic acid may play a therapeutic role in prion diseases, which provides a new method for the future research on prion disease Ideas.