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目的:基于食管鳞状细胞癌(ESCC)患者预后的相关危险因素,建立了一种预后评分系统,并进行验证。方法:回顾性分析2014年1月至2017年12月南通大学附属如皋医院135例ESCC患者的临床资料,均行食管癌根治性切除术,随访至2020年2月1日。根据预后将患者分为生存组(70例)和死亡组(65例)。通过Cox比例风险模型分析影响患者预后的危险因素,根据n HR值构建预后评分系统,并将患者按低、中、高死亡风险进行划分,比较不同死亡风险患者的预后。n 结果:135例患者中位随访时间41(3~72)个月,中位生存时间51个月。淋巴细胞与单核细胞比值(LMR)、预后营养指数(PNI)和C-反应蛋白(CRP)是影响ESCC患者预后的独立危险因素(n P<0.05)。低死亡风险患者1、3和5年累积生存率分别为96.7%、77.7%、65.2%,高于中死亡风险患者的91.7%、75.6%、37.1%及高死亡风险患者的87.9%、42.2%、26.8%,差异有统计学意义(n χ2=18.462,n P < 0.01)。n 结论:该评分系统是ESCC患者预后的有效评估系统,有助于临床医生对患者进行危险分层并给予个体化治疗。“,”Objective:To establish and validate the prognosis risk scoring system based on the prognostic risk factors of esophageal squamous cell carcinoma (ESCC).Methods:The clinical data of 135 patients with ESCC in Rugao Hospital Affiliated to Nantong University from January 2014 to December 2017 were retrospectively analyzed. All patients underwent radical resection of esophageal cancer and were followed up until February 1, 2020. According to prognosis, the patients were divided into survival group (70 cases) and death group (65 cases). Cox proportional hazard model was used to analyze the risk factors of affecting prognosis, and the prognostic risk scoring system was established according to the HR value. The patients were divided into low, medium and high risk of death, and the prognosis of patients with different death risk was compared.Results:The median follow-up time was 41 (3 to 72) months and the median survival time was 51 months. Lymphocyte to monocyte ratio (LMR), prognostic nutritional index (PNI) and C-reactive protein (CRP) were independent risk factors for the prognosis of ESCC patients (n P < 0.05). The 1-, 3- and 5-year cumulative survival rates of patients with low risk of death were 96.7%, 77.7% and 65.2%, respectively, which were higher than those of patients with moderate risk of death (91.7%, 75.6% and 37.1%) and those of patients with high risk of death (87.9%, 42.2% and 26.8%), and the difference was statistically significant ( n χ2 = 18.462, n P < 0.01).n Conclusions:The prognosis risk scoring system is an effective evaluation system for the prognosis of ESCC patients, which can help clinicians to stratify patients and perform individualized treatment.