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目的:探讨血清肌酸激酶同工酶电泳对于新生儿窒息后发生心肌、脑组织损伤中的应用价值。方法:回顾性分析2009年1月至12月我院儿科ICU送检的CK同工酶电泳检测结果,并按不同疾病诊断进行分组统计。结果:在HIE、新生儿窒息患儿血清中CK-BB分别占总CK的13.9±16.8%、2.6±3.1%,CK-MB分别占总CK的2.5±2.0%、8.2±7.5%;CK-MM分别占总CK的91.4±14.1%、94.0±5.8%。新生儿窒息组可见CK-MB增加,显著高于对照及HIE组(P<0.01);HIE组患儿血清中可见CK-BB增加,与对照组、新生儿窒息组比较均有显著性差异(P<0.01)。结论:CK同工酶电泳对诊断新生儿窒息后引起的心脑损伤有重要价值。
Objective: To investigate the value of serum creatine kinase isoenzyme electrophoresis in myocardial injury after neonatal asphyxia. Methods: The CK isozyme electrophoresis results of pediatric ICU were analyzed retrospectively from January to December in 2009, and were grouped according to the diagnosis of different diseases. Results: The serum levels of CK-BB in neonates with asphyxia were 13.9 ± 16.8% and 2.6 ± 3.1%, respectively, CK-MB were 2.5 ± 2.0% and 8.2 ± 7.5% MM accounted for 91.4 ± 14.1% of the total CK, 94.0 ± 5.8%. CK-MB increased in neonatal asphyxia group, which was significantly higher than that in control group and HIE group (P <0.01). CK-BB in serum of HIE group was significantly higher than that of control group and neonatal asphyxia group P <0.01). Conclusion: CK isoenzyme electrophoresis has important value in diagnosing cardiocerebral injury caused by neonatal asphyxia.