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目的： 探讨血源性乙型肝炎疫苗对乙型肝炎表面抗原（ ＨＢｓＡｇ） 阳性母亲的新生儿免疫持久性。方法：应用反向间接血凝反应（ ＲＰＨＡ） 法从１５００ 名孕妇中筛查出８２ 名ＨＢｓＡｇ ≥１∶６４ 的滴度阳性携带者的新生儿，分为疫苗组和对照组（ 人数比例为３∶１） 。疫苗组在新生儿出生２４ ｈ 内注射第１ 针，１ 月、６ 月龄分别注射第２ 针、３ 针乙肝疫苗，对照组按同样程序注射安慰剂。结果： 在第１３ 年时疫苗组抗ＨＢｓ 阳性率仍高达５９３２ ％ （３５／５９） ；对照组１３ 年中有２３５３ ％ （４／１７） 受到自然感染后变为抗ＨＢｓ 阳性，两组有显著性差异（ Ｐ＜ ００５） 。疫苗组的抗ＨＢｓ阳性者中，抗ＨＢｓＧＭＴ 峰值也在第１２ 个月，Ｓ／Ｎ 值为６８８４ ，到１３ 年时已下降到１７８２ ，相当于高峰的１／４ ，但仍明显高于对照组。除了出生时疫苗组与对照组ＨＢｓＡｇ 阳性率无明显差异外，疫苗组ＨＢｓＡｇ 阳性率一直明显低于对照组，在第１３ 年时疫苗组和对照组的ＨＢｓＡｇ 阳性率分别为６７７ ％ 、４７０６ ％ ，有显著性差异（ Ｐ＜ ００５） 。结论：ＨＢｓＡｇ 阳性母亲的新生儿进行乙型肝炎疫苗免疫１３ 年时，大部分仍有较好的?
Objective: To investigate the immune persistence of blood-borne hepatitis B vaccine in neonates with hepatitis B surface antigen (HBsAg) -positive mothers. Methods: Eighty-two newborns with positive titers of HBsAg ≥1: 64 were screened out from 1,500 pregnant women by reverse indirect hemagglutination (RPHA), divided into vaccine group and control group : 1). In the vaccine group, the first needle was injected within 24 hours of birth and the second and third doses of hepatitis B vaccine were injected in January and 6 months respectively. The control group received placebo in the same procedure. Results: The positive rate of anti-HBs in the vaccine group was still 5932% (35/59) at the 13th year. In the control group, 2353% (4/17) of the vaccine were naturally infected and became antiHBs Positive, there was a significant difference between the two groups (P <0 05). Anti-HBs positive in the vaccine group, anti- HBsGMT peak also in the twelfth month, S / N value of 68 84, 13 years had dropped to 17 82, equivalent to the peak of 1/4, but Still significantly higher than the control group. The positive rate of HBsAg in the vaccine group was significantly lower than that in the control group except for the positive rate of HBsAg in the vaccine group and the control group at the time of birth. The positive rate of HBsAg in the vaccine group and the control group was 677% and 47% respectively at the 13th year 06%, there was a significant difference (P <0 05). CONCLUSIONS: Most newborns with HBsAg-positive mothers are still better at 13 years of hepatitis B vaccine immunization?