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淋巴丝虫病是由班氏丝虫或马来丝虫引起的。目前通用的抗丝虫药物均缺乏抗丝虫成虫活性,且不适合作为预防药物。因此,开发能够调节丝虫发育的生物学过程,且对丝虫成虫和微丝蚴均有活性的新药和疫苗很有必要。作者以往的研究发现鼠表皮生长因子(mEGF)可使培养的马来微丝蚴核GTP酶Ran水平上调,而Stayer和Mathew的研究发现一种与Ran序列同源的蛋白质可以抑制EGF依赖的癌细胞株的增殖。作者进一步研究了EGF在丝虫幼虫发育中的作用。
Lymphatic filariasis is caused by Bancroftian filariasis or Malay filariasis. The current universal anti-filarial drugs are resistant to filarial adult activity, and is not suitable as a preventive drug. Therefore, it is imperative to develop new drugs and vaccines that are capable of regulating the biological processes of filamentous worm development and that are active against both filamentous adults and microfilariae. Previous studies by the authors found that mouse epidermal growth factor (mEGF) up-regulated the level of GTPase Ran in cultured M. marina, while studies by Stayer and Mathew found that a protein homologous to the Ran sequence can inhibit EGF-dependent cancers Proliferation of cell lines. The authors further studied the role of EGF in the development of filarial larvae.