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血管内皮细胞作为人体主要的代谢库,存在ACh ,并伴有ChAT的表达,有机阳离子载体(OCTs)参与血管内皮细胞ACh的转运和释放,血管内皮细胞AChE活性的广泛表达可以使非神经性ACh的活性仅仅局限于它的合成和释放区域,成为一种细胞因子。mAChR和nAChR同非神经性ACh一样,广泛存在于血管内皮细胞中,ACh通过其受体发挥重要的病理生理功能。nAChR参与血管内皮细胞多种生物活性物质的分泌和释放,其中α7受体在血管新生中发挥重要作用。非神经性ACh诱发内皮依赖的血管舒张反应,一种不同于神经性mAChR的血管内皮细胞非神经性M受体在其中发挥重要作用,并且在动脉粥样硬化和血栓的发生发展过程中起着重要的作用。
Vascular endothelial cells, as the main metabolic library of human, exist in ACh accompanied by the expression of ChAT. Organic cation carriers (OCTs) are involved in the transport and release of ACh in vascular endothelial cells. The extensive expression of AChE activity in vascular endothelial cells can make non-neuronal ACh Activity is limited to its synthetic and release regions and becomes a cytokine. Like non-neuronal ACh, mAChR and nAChR are found extensively in vascular endothelial cells, and ACh exerts important pathophysiological functions through its receptor. nAChR is involved in the secretion and release of many bioactive substances in vascular endothelial cells, of which α7 receptor plays an important role in angiogenesis. Non-neuronal ACh induces endothelium-dependent vasodilatory responses, a non-neuronal M receptor that is distinct from neuronal mAChR and plays a central role in the development of atherosclerosis and thrombosis Important role.