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发作性流涕、喷嚏及鼻堵是许多不同原因引起的鼻病常见症状。已知变应原时,这种发作往往是IgE 介导的反应。变应原与肥大细胞表面两个邻近受体上的特异性IgE 分子反应,引起细胞膜的改变,并使钙离子得以进入细胞内,引起肥大细胞脱颗粒,产生症状。无论什么原因,40%鼻息肉病人的上述鼻部症状是由于肥大细胞脱颗粒所致。在鼻息肉组织中可测得所有的免疫球蛋白,而且所有病人的鼻息肉组织都可局部产生IgE。作者用抗人IgE 测定了29例成年鼻息肉患者息肉的IgE 浓度,14例患者作了鼻息肉细胞的免疫过氧化酶染色,以确定浆细胞数,并用甲苯胺蓝复染法测定肥大细胞表面IgE 的量。结果发现
Episodic runny nose, sneezing and nasal blocking are many common causes of rhinopathy caused by different causes. When an allergen is known, this seizure is often IgE-mediated. Allergens react with specific IgE molecules on two adjacent receptors on the surface of mast cells, causing changes in the cell membrane and allowing calcium ions to enter the cell, causing mast cells to degranulate and produce symptoms. Whatever the reason, the above nasal symptoms in 40% of patients with nasal polyps are due to mast cell degranulation. All immunoglobulins can be measured in nasal polyps, and IgE is produced locally in all patients’ nasal polyps. The authors measured IgE concentrations in polyps of 29 adult patients with nasal polyps using anti-human IgE and immunoperoxidase staining of nasal polyps in 14 patients to determine the number of plasma cells and determine the surface of the mast cells using toluidine blue staining The amount of IgE. turn out