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目的:探讨尿微量白蛋白和尿肌酐测定对糖尿病肾病诊断的临床意义。方法:用德国欧宝XL-6OO全自动生化分析仪测定尿微量白蛋白(mAlb)和尿肌酐(Cr),糖尿病组403例,对照组150例。结果:糖尿病组尿mAlb(55.6±18.31)mg/L,显著高于对照(21.16±12.69)mg/L,差异有统计学意义(P<0.01)。尿mAlb/Cr糖尿病组(56.6±17.2)mg/g显著高于对照组(12.1±3.1)mg/g,差异有统计学意义(P<0.01)。结论:测定尿微量白蛋白和尿肌酐,是糖尿病肾病早期诊断一项重要指标。同时尿微量白蛋白和尿肌酐对2型糖尿病和高血压早期肾损害判定具有积极意义。
Objective: To investigate the clinical significance of urine microalbuminuria and urinary creatinine in the diagnosis of diabetic nephropathy. Methods: Urine microalbumin (mAlb) and urinary creatinine (Cr) were measured with German Opel XL-6OO automatic biochemistry analyzer. There were 403 cases of diabetic group and 150 cases of control group. Results: Urinary mAlb (55.6 ± 18.31) mg / L in diabetic group was significantly higher than that in control group (21.16 ± 12.69) mg / L, the difference was statistically significant (P <0.01). Urinary mAlb / Cr diabetes group (56.6 ± 17.2) mg / g was significantly higher than the control group (12.1 ± 3.1) mg / g, the difference was statistically significant (P <0.01). Conclusion: The determination of urinary albumin and urinary creatinine is an important indicator of early diagnosis of diabetic nephropathy. At the same time, urinary microalbuminuria and urinary creatinine have positive significance for the determination of type 2 diabetes mellitus and early renal damage in patients with hypertension.