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目的探讨近红外波辅助治疗慢性乙型肝炎(CHB)及乙型肝炎后肝硬化的临床疗效。方法选择CHB患者54例,随机分为治疗组与对照组(各27例);肝硬化患者12例,随机分为治疗组与对照组(各6例)。对照组应用抗病毒药物和保肝药物治疗,治疗组在对照组治疗基础上使用近红外波治疗,比较两组治疗效果。结果两组CHB患者实际住院天数,症状改善时间差异均有统计学意义(P=0.041、0.015);治疗后丙氨酸氨基转移酶(ALT)复常差异无统计学意义(P=0.082);治疗后白细胞(WBC)、血红蛋白(HB)、乙型肝炎病毒表面抗原(HBsAg)比较,差异均无统计学意义(P=0.560、0.471、0.520)。治疗组CHB患者血小板(PLT)显著高于对照组(P=0.001)。乙型肝炎后肝硬化患者治疗组实际住院天数、ALT与对照组比较,差异均有统计学意义(P=0.021、0.023);治疗后症状改善时间与对照组比较,差异无统计学意义(P=0.075);治疗后WBC、HB、HBsAg比较,差异均无统计学意义(P=0.721、0.562、0.895)。治疗组肝硬化患者治疗后PLT数量与对照组比较,差异有统计学意义(P=0.012)。结论近红外波辅助治疗乙型肝炎及肝硬化患者具有一定的临床疗效,可作为乙型肝炎及肝硬化患者的辅助治疗手段。
Objective To investigate the clinical effects of near infrared wave in the treatment of chronic hepatitis B (CHB) and post-hepatitis B cirrhosis. Methods Fifty-four CHB patients were randomly divided into treatment group and control group (27 cases each), and patients with cirrhosis were randomly divided into treatment group and control group (6 cases each). The control group was treated with antiviral drugs and hepatoprotective drugs. The treatment group was treated with near-infrared wave based on the control group, and the treatment effect was compared between the two groups. Results There were significant differences in the actual length of hospital stay and symptom improvement between the two groups (P = 0.041,0.015). There was no significant difference in the normalization of alanine aminotransferase (ALT) between the two groups (P = 0.082). There was no significant difference in WBC, HB, HBsAg after treatment (P = 0.560, 0.471, 0.520). The platelet count (PLT) of CHB patients in the treatment group was significantly higher than that in the control group (P = 0.001). The actual hospitalization days in patients with post-hepatitis B cirrhosis were significantly different (P = 0.021, 0.023). There was no significant difference in ALT between the treatment group and the control group = 0.075). There was no significant difference in WBC, HB, HBsAg after treatment (P = 0.721, 0.562, 0.895). The number of PLT after treatment in patients with cirrhosis in the treatment group was significantly different from that in the control group (P = 0.012). Conclusion Near infrared wave assisted therapy for patients with hepatitis B and cirrhosis has some clinical efficacy, can be used as adjunctive therapy in patients with hepatitis B and cirrhosis.