美国FDA告诫职业医务工作者及广大病人,母亲妊娠期间胎儿暴露于丙戊酸盐(valproate)及相关药物(丙戊酸与丙戊酰钠),可增加新生儿神经元结节及其他重要畸形,如颜面缺损及心血管畸形。根据FDA的资料,美国一般人群中,新生儿神经元结节缺损发生率为1/1500,而母亲妊娠前3个月服用该药,婴儿出生后神经元结节缺损发生率为1/20, The U.S. FDA warned that occupational health workers and the vast majority of patients whose mothers during pregnancy are exposed to valproate and related drugs (valproate and valproate) may increase neonatal neuronal nodules and other important deformities , Such as facial defects and cardiovascular malformations. According to FDA data, the general population of the United States, neonatal neuronal nodular defect incidence of 1/1500, while the mother took the drug 3 months before pregnancy, the incidence of postnatal neuronal nodular defects was 1/20,