耐药细菌引起的重症感染临床选药原则避开耐药机制当前临床分离菌对常用抗生素耐药的问题已相当严重。在临床选药时,要避开细菌的耐药机制(见下表)。选用碳青霉烯类抗生素治疗的适应证是败血症、呼吸机相关肺炎、免疫低下伴感染和复杂的腹部感染;由产ESBLs、AmpCs和SSBLs酶的细 Drug-resistant bacteria caused by severe infection Clinical principles of drug selection to avoid drug resistance The current clinical isolates of commonly used antibiotic resistance problems have been quite serious. In clinical drug selection, to avoid bacterial resistance mechanism (see table below). Indications for use of carbapenem-based antibiotics are sepsis, ventilator-associated pneumonia, immunocompromised infections, and complicated abdominal infections. The indications of ESBLs, AmpCs and SSBLs