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目的 研究支气管哮喘、慢性阻塞性肺疾病急性发作期常规治疗同时抗胃食管返流治疗前后血清内皮素、一氧化氮变化及临床意义。方法 采用双抗体夹心法、硝酸还原酶法测定 39例哮喘、COPD伴 GER患者抗返流治疗前后 NO、ET,并与 30例对照组未抗返流治疗前后 NO、ET进行比较。结果 未抗返流组治疗前后 NO、ET含量比较差异无显著性。抗返流组治疗前后 NO、 ET、 Pa O2 、 Pa CO2 、 FEV1 .0 有显著性差异 (P<0 .0 1) ;抗返流组治疗前后ET与 Pa CO2 呈正相关 (r=0 .4 86 P<0 .0 1)。结论 胃食管返流是哮喘、COPD诱发或加重原因之一。作者认为哮喘 ,COPD急性发作期除常规治疗同时予以抗返流治疗有良好的临床意义。
Objective To study the changes of serum endothelin and nitric oxide in patients with bronchial asthma and acute exacerbation of chronic obstructive pulmonary disease before and after anti-gastroesophageal reflux treatment and its clinical significance. Methods The levels of NO and ET in 39 asthmatic patients and COPD patients with GER before and after anti-reflux therapy were determined by double antibody sandwich method and nitrate reductase method. The levels of NO and ET were compared with those of 30 control subjects before and after anti-reflux therapy. Results Before and after treatment, the levels of NO and ET in non-anti-reflux group were not significantly different. The levels of NO, ET, PaO 2, PaCO 2 and FEV 1 .0 in the anti-reflux group were significantly different before and after treatment (P 0. 01) 86 P <0 .0 1). Conclusion Gastroesophageal reflux is one of the causes of asthma and COPD induced or exacerbation. The authors believe that asthma, acute exacerbation of COPD in addition to conventional anti-reflux therapy to treat with good clinical significance.