吸吮及运动时催乳素分泌增加。在正常的睡眠-觉醒周期中,催乳素的释放也有昼夜节律。Quigley新近报告,在正常妇女,进食与急性催乳素释放之间存在密切的时间相关。在月经周期规律的正常妇女进行了20次实验。经静脉插管每隔15分钟取血一次,用放射免疫分析法测定血清催乳素。8例受试者于12点进午餐;4例于下午2点进午餐;8例自晨8点至下午4点之间禁食作为对照。在8例于12点进午餐及下午5点进晚餐的受试者,连续取血至晚8时,以观察血清催乳素水平与进餐时间的关系。结果表明,禁食受试者的催乳素水平呈现明显的昼夜节律,清晨下降而正午12点以后逐渐升高。以此为对照,在不同时间进午餐的受试者,进餐开始后的45分钟内均呈现突发性催乳素水平升高。于下午5点 Sucking and exercise prolactin secretion increased. During normal sleep-wake cycles, there is also a circadian rhythm of prolactin release. Quigley recently reported that there is a close temporal correlation between eating and acute prolactin release in normal women. The normal menstrual cycle of regular women conducted 20 experiments. Blood was collected every 15 minutes via intravenous intubation and serum prolactin was measured by radioimmunoassay. Eight subjects had lunch at 12 o’clock; 4 patients had lunch at 2 o’clock; and 8 patients had fasted between 8am and 4pm as control. Eight subjects, who had lunch at 12 o’clock and had dinner at 5 p.m., were continuously bled to night at 8 o’clock in order to observe the relationship between serum prolactin level and mealtime. The results showed that fasting subjects showed a significant circadian rhythm of prolactin levels, decreased in the morning and gradually increased after 12 noon. As a control, subjects who had lunch at different times showed elevated levels of prolactin within 45 minutes after the meal began. At 5 p.m.