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目的探讨布洛芬微乳的制备及其透皮吸收。方法对布洛芬微乳的分布和粒度、布洛芬微乳的稳定性、头皮速率以及含量分别用粒度分析仪以及ZETAPALS多功能电位进行测定、稳定性试验来考察、改进的Franz扩散池进行研究以及高效液相色谱法来测定。结果 57.9nm是布洛芬微乳乳滴的平均粒径;其稳定性良好;(189.79±11.71)μg·cm-2·h-1为平均透皮速率,透皮吸收行为与FICK’S定义定律相符合。结论布洛芬微乳的透皮能力比较强,在不久的将来会替代布洛芬成为一种全新的透皮给药制剂。
Objective To investigate the preparation and transdermal absorption of ibuprofen microemulsion. Methods The distribution and particle size of ibuprofen microemulsion, the stability of ibuprofen microemulsion, the scalp rate and the content of the ibuprofen microemulsion were measured respectively with the particle size analyzer and the ZETAPALS multifunction potential, and the stability test. The improved Franz diffusion cell Research and high performance liquid chromatography. Results 57.9nm was the average particle size of ibuprofen microemulsion droplets with good stability. The average transdermal rate was (189.79 ± 11.71) μg · cm-2 · h-1. The transdermal absorption behavior was related to the Fick’s law meets the. Conclusion The ibuprofen microemulsion has strong transdermal ability and will replace ibuprofen as a new transdermal drug delivery agent in the near future.