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目的了解儿童医院住院患儿感染沙门菌临床分布及耐药性变迁。方法通过回顾性调查和药敏试验方法,对武汉市某儿童医院住院患儿临床送检标本进行沙门菌分离鉴定和药敏试验。结果该医院住院患儿临床送检标本检出沙门菌176株,主要有猪霍乱沙门菌、伦敦沙门菌和鼠伤寒沙门菌,感染患儿较高的科室是消化内科。临床分离的沙门菌对氨苄西林和氯霉素的耐药率高达67.7%~91.2%,对头孢他啶和复方新诺明耐药率呈现增长趋势,对左氧氟沙星比较敏感。结论该儿童医院近5年间临床分离的沙门菌对抗菌药物的耐药性普遍增高,多重耐药沙门菌分离率明显增加,提示加强对儿童住院患者的防控措施。
Objective To understand the clinical distribution and drug resistance of Salmonella in children hospitalized in Children’s Hospital. Methods By retrospective investigation and susceptibility testing methods, the isolation and identification of Salmonella in clinical samples of hospitalized children in a Children ’s Hospital of Wuhan were carried out. Results The hospital inpatient samples were detected in Salmonella 176 specimens, mainly Salmonella choleraesuis, Salmonella typhimurium and Salmonella typhimurium, infected children with higher department is the Department of Gastroenterology. Salmonella clinical isolates of ampicillin and chloramphenicol resistance rates as high as 67.7% to 91.2%, ceftazidime and cotrimoxazole resistance rates showed an upward trend, more sensitive to levofloxacin. Conclusion The clinical isolation of Salmonella isolates from the hospital in the past five years has generally increased the resistance to antibiotics, and the isolation rate of multi-resistant Salmonella has been significantly increased, suggesting that the prevention and control measures should be strengthened for children hospitalized.