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目的探讨高效液相色谱法(HPLC)检测羊水卵磷脂/鞘磷脂(L/S)比值产前预测新生儿呼吸窘迫综合征(RDS)的价值。方法对55例羊水标本采用HPLC检测羊水L/S比值,受试者工作特征曲线(ROC)分析HPLC检测羊水L/S比值产前预测RDS的效率。结果 RDS组羊水L/S比值明显低于非RDS组,差异有统计学意义[(4.14±1.80)vs.(19.56±15.76)],P<0.05)。羊水L/S比值以5.778为切割值,L/S比值产前预测RDS的ROC曲线下面积为0.969,灵敏度和特异度分别为92.3%和95.2%。结论 HPLC检测羊水L/S比值产前预测RDS是一种非常有潜力可用于临床的理想方法。
Objective To investigate the value of high performance liquid chromatography (HPLC) in detecting amniotic fluid lecithin / sphingomyelin (L / S) ratio in predicting neonatal respiratory distress syndrome (RDS) before delivery. Methods The amniotic fluid L / S ratio was measured by HPLC in 55 cases of amniotic fluid samples. The receiver operating characteristic curve (ROC) analysis was used to detect the L / S ratio of amniotic fluid to predict the efficiency of prenatal RDS. Results The amniotic fluid L / S ratio in RDS group was significantly lower than that in non-RDS group (4.14 ± 1.80 vs. 19.56 ± 15.76, P <0.05). The L / S ratio of amniotic fluid was 5.778. The area under the ROC curve of prenatal RDS with L / S ratio was 0.969, the sensitivity and specificity were 92.3% and 95.2% respectively. Conclusions HPLC detection of amniotic fluid L / S ratio prenatal prediction of RDS is a very potential ideal for clinical use.