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目的:检测CD4 4v6mRNA和HSP70mRNA在胃癌组织中的表达,探讨CD4 4v6mRNA和HSP70mRNA在胃癌发生发展中的作用。方法:利用核酸原位杂交技术对39例胃癌组织进行检测。结果:CD4 4v6mRNA和HSP70mRNA在胃癌组织表达的阳性率都为6 1.5 4% (2 4 / 39) ,CD4 4v6mRNA和HSP70mRNA在高分化管状腺癌与低分化管状腺癌中的表达都有显著性差异(P <0 .0 5 ) ,但HSP70mRNA在胃癌组织的表达与性别、年龄、浸润深度及淋巴结有无转移都无关(P >0 .0 5 ) ,而CD4 4v6mRNA与淋巴结有无转移有关(P <0 .0 5 )。结论:CD4 4v6mRNA和HSP70mRNA在胃癌组织都有较高的表达,两者均可作为评估胃癌预后的指标。
Objective: To detect the expression of CD4 4v6 mRNA and HSP70 mRNA in gastric cancer and to explore the role of CD4 4v6 mRNA and HSP70 mRNA in the development of gastric cancer. Methods: 39 cases of gastric cancer tissues were detected by in situ hybridization. Results: The positive rates of CD4 4v6 mRNA and HSP70 mRNA in gastric cancer tissues were all 6 1.54% (4/39). The expressions of CD4 4v6 mRNA and HSP70 mRNA in well-differentiated and poorly differentiated tubular adenocarcinomas were significantly different (P <0.05), but there was no correlation between the expression of HSP70mRNA and the gender, age, depth of invasion and lymph node metastasis (P> 0.05), but there was no correlation between the expression of HSP70mRNA and lymph node metastasis <0 .0 5). Conclusion: CD4 4v6 mRNA and HSP70 mRNA are highly expressed in gastric cancer tissues, both of which can be used as an index to evaluate the prognosis of gastric cancer.