慢性中性粒细胞性白血病 (CNL )为骨髓增殖性疾病 ,一般呈慢性过程 ,很少发生急变。我们观察到 1例 CNL 发生极低分化急性髓细胞白血病 (AML-M0 )急变的病例 ,报告如下。患者 ,女 ,64岁。1989年 2月首次入院。患者因鼻出血就医 ,在入院前 2个月内 ,血中 WBC多次 2 0× 10 9/L Chronic neutrophilic leukemia (CNL) is a myeloproliferative disease that is generally a chronic process with little or no immediate change. We observed a case of acute degeneration of CNL with very poorly differentiated acute myeloid leukemia (AML-M0), the report is as follows. Patient, female, 64 years old. February 1989 first admission. Patients due to nose bleeding for medical treatment, within 2 months before admission, blood WBC many times 20 × 10 9 / L