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目的:研究白沙蒿全草的化学成分。方法:采用硅胶、Sephadex LH-20柱色谱等方法对其化学成分进行分离纯化,通过化合物的理化性质和波谱数据鉴定其结构。结果:从白沙蒿全草中分离鉴定了15个化合物,分别为5-羟基-7,4’-二甲氧基二氢黄酮(1),5-羟基-7,4’-二甲氧基黄酮(2),3,5-二羟基-7,4’-二甲氧基二氢黄酮(3),5,3’-二羟基-7,4’-二甲氧基二氢黄酮(4),5,7-二羟基-6,4’-二甲氧基黄酮(5),异野樱素(6),橙皮素(7),柑桔素(8),金合欢素(9),金圣草黄素(10),5,7-二羟基-4’-甲氧基-6,8-二-C-β-葡萄糖苷(11),香蜂草苷(12),金合欢素-7-O-芸香糖苷(13),云杉苷(14),茵陈素(15)。结论:化合物1～3,5,7～8,10～15均为首次从该植物中分离得到。
Objective: To study the chemical constituents of Artemisia annua. Methods: The chemical constituents were separated and purified by silica gel and Sephadex LH-20 column chromatography. Their structures were identified by physicochemical properties and spectral data. Results: Fifteen compounds were isolated and identified from the whole plant Artemisia annua L. They were 5-hydroxy-7,4’-dimethoxyflavanone (1), 5-hydroxy-7,4’-dimethoxy Flavone (2), 3,5-dihydroxy-7,4’-dimethoxyflavanone (3), 5,3’-dihydroxy-7,4’-dimethoxyflavanone ), 5,7-dihydroxy-6,4’-dimethoxyflavone (5), isosafrole (6), hesperetin (7), citrus (8) (10), 5,7-dihydroxy-4’-methoxy-6,8-di-C-β-glucoside (11), lemon balm (12), gold Acacidin-7-O-rutinoside (13), sprucoside (14), caprine (15). Conclusion: Compounds 1 ~ 3,5,7 ~ 8 and 10 ~ 15 were isolated from this plant for the first time.