The cyclonic-static micro-bubble flotation column(FCSMC) is a highly efficient mineral processing equipment. In this study, a cell-column(FCSMC) integration process was investigated for the separation of bauxite and its feasibility was analyzed on a theoretical basis. The properties of low-grade bauxite ore from Henan Province, China were analyzed. Parameters such as reagent dosage, scraping bubble time, and pressure of the circulating pump during the sorting process were investigated and optimized to improve the flotation efficiency. On the basis of these parameters, continuous separation experiments were conducted. Bauxite concentrate with an aluminum-to-silicon(A/S) mass ratio of 6.37 and a 77.63wt% recovery rate were achieved via a flow sheet consisting of “fast flotation using a flotation cell, one roughing flotation and one cleaning flotation using flotation columns”. Compared with the full-flotation-cells process, the cell?column integration process resulted in an increase of the A/S ratio by 0.41 and the recovery rate by 17.58wt%. Cell?column integration separation technology represents a new approach for the separation of middle-to-low-grade bauxite ore. The cyclonic-static micro-bubble flotation column (FCSMC) is a highly efficient mineral processing equipment. In this study, a cell-column (FCSMC) integration process was investigated for the separation of bauxite and its feasibility was analyzed on a theoretical basis. The properties of low-grade bauxite ore from Henan Province, China were analyzed. Parameters such as reagent dosage, scraping bubble time, and pressure of the circulating pump during the sorting process were investigated and optimized to improve the flotation efficiency. On the basis of these parameters, continuous separation experiments carried conducted. Bauxite concentrate with an aluminum-to-silicon (A / S) mass ratio of 6.37 and a 77.63 wt% recovery rate were achieved via a flow sheet consisting of “fast flotation using a flotation cell One roughing flotation and one cleaning flotation using flotation columns ”Compared with the full-flotation-cells process, the cell? column integration process resulted in an increase of the A / S ratio by 0.41 and the recovery rate by 17.58 wt%. Cell ™ column integration separation technology represents a new approach for the separation of middle-to-low-grade bauxite ore.