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成人中微小病毒B19感染率高达50％～70％。该病毒易侵袭骨髓或胎肝内未成熟红细胞,抑制红细胞形成,导致贫血。有报道微小病毒B19感染引起妊娠中晚期胎儿水肿、自然流产和胎死宫内。但微小病毒B19感染导致的非水肿性妊娠晚期胎儿死亡尚未引起足够的重视。 1992～1998年,经超声确诊的妊娠晚期胎死宫内共93例,于36h内发动分娩。产后收集胎盘组织及母血,于24h内储存于-20℃。另取胎盘组织用甲醛固定并用石蜡包埋。部分死胎作尸解并取组织活检。以荧光免疫法检测母血清中抗微小病毒B19IgG和IgM。以PCR法检测胎盘组织、母血清及胎
Infection with B19 in adults is as high as 50% to 70%. The virus is easy to invade bone marrow or fetal liver immature red blood cells, inhibit the formation of red blood cells, leading to anemia. It has been reported that parvovirus B19 infection causes late pregnancy fetal edema, spontaneous abortion and fetal death. However, non-edematous third trimester fetal death caused by parvovirus B19 infection has not received sufficient attention. From 1992 to 1998, a total of 93 cases of fetal death in the third trimester of pregnancy were diagnosed by ultrasound and delivered within 36 hours. Postpartum placental tissue collection and maternal blood, stored at -20 ℃ within 24h. Another placenta tissue fixed with formaldehyde and embedded with paraffin. Part of stillbirth for autopsy and tissue biopsy. Detection of anti-parvovirus B19 IgG and IgM in maternal serum by fluorescence immunoassay. PCR method to detect placental tissue, serum and fetal