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目的 :探讨成人双表型急性白血病 (BAL)的临床特征、生物学特性、治疗效果及预后。方法 :采用流式细胞仪分析急性白血病的免疫表型 ,根据EGIL标准诊断BAL。结果 :成人BAL的构成比为 8.9% ,CD3 4 表达阳性率为 75 .0 % ,P170表达阳性率为 70 .0 % ,明显高于同期非BAL(均 P <0 .0 5 ) ;12例患者治疗后完全缓解率为 33.3% ,12个月总生存率为 8.3% ,明显低于同期非BAL(P <0 .0 5 ,P <0 .0 1) ;其疗效与CD3 4 和P170的表达呈负相关。结论 :BAL常伴有较多的不良预后因素 ,治疗效果差 ,生存期短 ,合适的治疗方案还有待于进一步探讨
Objective: To investigate the clinical features, biological characteristics, therapeutic effect and prognosis of adult patients with dual-phenotype acute leukemia (BAL). Methods: The immunophenotype of acute leukemia was analyzed by flow cytometry and BAL was diagnosed according to EGIL criteria. Results: The ratio of adult BAL was 8.9%, the positive rate of CD3 4 was 75.0%, the positive rate of P170 was 70.0%, significantly higher than that of non-BAL in the same period (all P <0.05); 12 The complete remission rate was 33.3% after treatment and the overall survival rate at 12 months was 8.3%, which was significantly lower than that of the non-BAL (P <0.05, P <0.01) Expression was negatively correlated. Conclusion: BAL often accompanied by more adverse prognostic factors, the treatment effect is poor, short survival, the appropriate treatment needs to be further explored