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目的了解大连市区人群血尿酸水平与高尿酸血症患病率及其影响因素。方法对进行健康体检的2067名大连市民的血尿酸、血糖、血脂水平及一些基础指标进行分析,用尿酸酶法检测血尿酸含量。结果(1)男性血尿酸平均值为(376±79)μmol/L,女性为(309±67)μmol/L;男性高尿酸血症患病率为19.2%,女性为15.1%;男性均显著高于女性(P<0.01),且不同年龄组之间有统计学差异(P<0.05)。(2)超重和肥胖人群中血尿酸水平和高尿酸血症患病率显著增高(P<0.01)。(3)高尿酸血症组FBG、TG、LDL-C和TC水平明显高于血尿酸正常组(P<0.05)。(4)高尿酸血症组高TG血症、超重和肥胖、高血糖、高血压和高LDL-C血症的检出率显著高于血尿酸正常组。结论大连地区血尿酸水平和高尿酸血症患病率较高,肥胖容易引发高尿酸血症,高尿酸血症更容易伴发高血脂、高血糖和高血压等代谢性疾病,应该引起重视、加强控制。
Objective To understand the blood uric acid level and the prevalence of hyperuricemia and its influencing factors in urban residents of Dalian. Methods Blood uric acid, blood glucose, blood lipid levels and some basic indicators of 2,067 Dalian residents were analyzed. Uric acid enzymatic method was used to detect serum uric acid. Results (1) The average serum uric acid was (376±79) μmol/L in males and (309±67) μmol/L in females; the prevalence of hyperuricemia was 19.2% in males and 15.1% in females; all males were significant. Higher than women (P <0.01), and statistically significant differences between different age groups (P <0.05). (2) The serum uric acid level and the prevalence of hyperuricemia were significantly higher in overweight and obese subjects (P<0.01). (3) The levels of FBG, TG, LDL-C and TC in hyperuricemia group were significantly higher than those in normal blood uric acid group (P<0.05). (4) The rates of hypertriglyceridemia, overweight and obesity, hyperglycemia, hypertension, and high LDL-C in the hyperuricemia group were significantly higher than those in the normal uric acid group. Conclusion The blood uric acid level and the prevalence of hyperuricemia are higher in Dalian. Obesity is prone to cause hyperuricemia. Hyperuricemia is more likely to be accompanied by metabolic diseases such as hyperlipidemia, hyperglycemia, and hypertension. Strengthen control.