人们发现多不饱和脂肪酸(PUFA)有降血胆固醇及防止动脉粥样硬化的作用已有30余年了。1970年,Grundy和Ahrens首次系统地分析了PUFA降血胆固醇的可能机理,他们认为PUFA降血胆固醇作用是通过:1.促进胆汁酸或/和中性固醇在粪便中的排泄;2.减少小肠对胆固醇的吸收;3.减少内源性胆固醇的合成;4.使循环胆固醇在血浆和组织中重新分配而实现的。然而,近年来对PUFA降血胆固醇机理研究的深入和发展,使人们对 It has been found that polyunsaturated fatty acids (PUFA) have the effect of lowering blood cholesterol and preventing atherosclerosis for more than 30 years. Grundy and Ahrens first systematically analyzed the hypocholesterolemic mechanism of PUFA in 1970. They concluded that the hypocholesterolemic effect of PUFA is achieved by: 1. promoting the excretion of bile acids and / or neutral sterols in feces; 2. reducing Intestinal absorption of cholesterol; 3. Reduce the synthesis of endogenous cholesterol; 4. Circulation of cholesterol in plasma and tissue redistribution achieved. However, in recent years, the depth and development of the research on the mechanism of hypocholesterolemia in PUFA have made people right