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目的探讨血清胱抑素C水平和尿微量白蛋白水平诊断妊娠期高血压疾病的临床价值与意义。方法选取2015年2月-2016年2月在华中科技大学医院进行治疗的120例妊娠期高血压疾病患者作为病例组,再按照患者病情的严重程度分为妊娠期高血压组50例、轻度子痫前期组40例、重度子痫前期组30例。选取同期进行检查的健康孕妇100例作为对照组。检查并比较各组患者血清胱抑素C水平、尿微量白蛋白水平、尿素氮水平、肌酐水平。分析病例组患者血清胱抑素C水平与尿微量白蛋白水平的相关性。结果病例组的血清胱抑素C水平、尿微量白蛋白水平、尿素氮水平、肌酐水平均显著高于对照组(P<0.05),轻度子痫前期组、妊娠期高血压疾病组患者的血清胱抑素C水平、尿微量白蛋白水平比较,差异具有统计学意义(P<0.05),而两组患者的尿素氮水平、肌酐水平比较,差异无统计学意义(P>0.05),轻度子痫前期组患者与重度子痫前期患者组的血清胱抑素C水平、尿微量白蛋白水平、尿素氮水平、肌酐水平比较,差异均具有统计学意义(P<0.05)。相关性分析显示,病例组患者的血清胱抑素C水平与尿微量白蛋白水平呈正相关(r=0.845,P<0.05)。结论妊娠期高血压疾病患者在发病早期就存在血清胱抑素C和尿微量白蛋白水平升高的问题,检测血清胱抑素C水平与尿微量白蛋白水平对早期诊断妊娠期高血压疾病具有十分重要的临床价值。
Objective To investigate the clinical value and significance of serum cystatin C and urinary microalbuminuria in the diagnosis of gestational hypertension. Methods A total of 120 cases of hypertensive disorder complicating pregnancy were treated in Huazhong University of Science and Technology from February 2015 to February 2016 as the case group and then divided into 50 cases of gestational hypertension according to the severity of the patient’s condition. 40 cases of preeclampsia and 30 cases of severe preeclampsia. Select the same period for examination of 100 healthy pregnant women as a control group. The levels of serum cystatin C, urine microalbumin, urea nitrogen and creatinine were examined and compared in all groups. The correlation between serum cystatin C level and urinary microalbumin level was analyzed in case group. Results Serum levels of cystatin C, urine microalbuminuria, urea nitrogen and creatinine were significantly higher in the patients with mild preeclampsia and gestational hypertension than those in the control group (P <0.05) Serum levels of cystatin C and urine microalbumin had statistical significance (P <0.05). There was no significant difference between the two groups in the levels of urea nitrogen and creatinine (P> 0.05) The levels of serum cystatin C, urine microalbuminuria, blood urea nitrogen and creatinine in patients with preeclampsia and severe preeclampsia were significantly different (P <0.05). Correlation analysis showed that the level of serum cystatin C was positively correlated with urinary microalbumin (r = 0.845, P <0.05). Conclusions There is an increasing serum cystatin C and urinary microalbuminuria in patients with hypertensive disorder complicating pregnancy at the early stage of pregnancy. The detection of serum cystatin C and urinary microalbumin level have the following effects on early diagnosis of hypertensive disorder complicating pregnancy: Very important clinical value.