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目的探讨血液灌流 (HP)治疗重度急性有机磷农药中毒 (AOPP)的临床疗效。方法 5 9例重度 AOPP患者随机分为 HP组和非HP组 ,HP组在综合治疗的基础上予以 HP治疗。通过观察两组的昏迷到清醒时间、呼吸肌麻痹发生率、存活率及平均住院天数 4项指标来判断 HP的临床疗效。结果 HP组存活率 96.67% ,显著优于非 HP组 68.97% (P<0 .0 5 ) ;HP后无一例发生呼吸肌麻痹 ,非 HP组均出现呼吸肌麻痹。结论 HP能有效清除体内有机磷 ,预防呼吸肌麻痹的发生 ,提高存活率 ,HP治疗 AOPP疗效显著
Objective To investigate the clinical effect of hemoperfusion (HP) on severe acute organophosphorus pesticide poisoning (AOPP). Methods Fifty-nine patients with severe AOPP were randomly divided into HP group and non-HP group. HP group was treated with HP on the basis of comprehensive treatment. By observing the coma of the two groups to awake time, the incidence of respiratory muscle paralysis, the survival rate and the average length of hospital stay 4 indicators to determine the clinical efficacy of HP. Results The survival rate of HP group was 96.67%, which was significantly higher than that of non-HP group (68.97%, P <0.05). No respiratory muscle paralysis was found in HP group and paralysis of respiratory muscle in non-HP group. Conclusion HP can effectively remove organophosphate from the body, prevent the occurrence of respiratory muscle paralysis and improve the survival rate, HP treatment AOPP significant effect