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目的 :探究在乳腺恶性肿瘤的诊断中肿瘤标记物糖类蛋白抗原153和癌胚抗原的联合临床诊断意义。方法 :选取2013年1月至2014年12月在本院诊治的乳腺恶性肿瘤患者80例为观察组,选取同期在本院诊治的良性乳腺疾病患者以及健康人员各80例为良性对照组和健康对照组,对3组观察对象清晨空腹静脉血进行采集,然后进行血清分离提取,进一步对糖类蛋白抗原153和癌胚抗原指标进行检测。结果:在3组观察对象的血清肿瘤标记物检测中,观察组糖类蛋白抗原153和癌胚抗原均显著高于良性对照组和健康对照组,差异具有统计学意义(P<0.05);观察组的糖类蛋白抗原153检测敏感性和特异性分别为67.5%(54/80)、90.0%(72/80),观察组的癌胚抗原检测敏感性和特异性分别为31.3%(25/80)、88.8%(71/80),其联合检测的敏感性为85.0%(68/80),联合检测的敏感性明显高于单独检测敏感性。结论:在乳腺恶性肿瘤的诊断中,肿瘤标记物的联合检测能够显著提高乳腺恶性肿瘤的诊断敏感性,在临床应用中有很好的价值。
Objective: To explore the clinical significance of combination of tumor markers carbohydrate antigen 153 and carcinoembryonic antigen in the diagnosis of breast malignant tumors. Methods: Eighty patients with breast cancer who were diagnosed and treated in our hospital from January 2013 to December 2014 were selected as the observation group. Eighty patients with benign breast disease and healthy persons who were treated in our hospital during the same period were selected as benign control group and healthy group In the control group, the fasting venous blood was collected in the early morning of the three groups, then the serum was separated and extracted to further detect the carbohydrate antigen 153 and carcinoembryonic antigen. Results: In the detection of serum tumor markers in the three groups, the levels of carbohydrate antigen 153 and carcinoembryonic antigen in the observation group were significantly higher than those in the benign control group and the healthy control group (P <0.05). Observation The detection sensitivity and specificity of the group of carbohydrate antigen 153 were 67.5% (54/80) and 90.0% (72/80), respectively. The sensitivity and specificity of the detection of carcinoembryonic antigen in the observation group were 31.3% (25 / 80) and 88.8% (71/80) respectively. The sensitivity of combined detection was 85.0% (68/80). The sensitivity of combined detection was significantly higher than that of single detection. Conclusion: In the diagnosis of breast cancer, the combined detection of tumor markers can significantly improve the diagnostic sensitivity of breast cancer, which is of great value in clinical application.