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背景 已有报导输血反应与中性粒细胞5b抗原有关,而在新生儿同种免疫性中性粒细胞减少症未见报导。病例报告在一个持续中性粒细胞减少新生儿母亲的血清中检出了抗-5b,该新生儿已被几种细菌感染。用重组粒细胞集落刺激因子对这种中性粒细胞减少症治疗有效。用新检出的5b抗血清以及另外3种5b抗血清做免疫沉淀反应试验,鉴定出一种分子量为75
Background It has been reported that the transfusion reaction is associated with neutrophil 5b antigen, whereas no alloimmune neutropenia has been reported in neonates. Case Reports Anti-5b was detected in the serum of a neutropenic neonatal mothers who had been infected with several bacteria. Recombinant granulocyte colony-stimulating factor is effective in the treatment of this neutropenia. An immunoprecipitation assay was performed using the newly detected 5b antiserum plus three additional 5b antisera to identify a peptide with a molecular weight of 75