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观察创伤性休克过程中血浆内皮素与组织氧分压的动态变化 ,探讨内皮素在创伤性休克过程中的意义。采用后肢创伤法建立创伤性休克大鼠模型 ,观察创伤前后血浆内皮素、动脉血气分析及骨骼肌、肝脏、小肠的组织氧分压的动态变化 ,监测血流动力学变化并记录存活时间。结果显示 ,创伤休克后血浆内皮素浓度迅速升高 ,显著高于伤前水平 ,复苏 7h浓度达到伤前水平的 2 5倍左右 ;休克后动脉血气各项指标及组织氧分压较创伤前有显著性差异 ,休克后出现失代偿性酸中毒 ,肝脏及小肠的氧分压变化较骨骼肌更为显著。提示创伤性休克后血浆内皮素显著升高 ,在早期对于维持血压有重要意义 ,但在休克后期可能是造成死亡的重要原因 ;内脏器官氧分压的不可逆性降低 ,可能是休克后期不易复苏的关键因素。
To observe the dynamic change of plasma endothelin and tissue partial pressure of oxygen during traumatic shock and to explore the significance of endothelin during traumatic shock. The rat model of traumatic shock was established by hindlimb trauma. The changes of plasma endothelin, arterial blood gas and tissue oxygen tension in skeletal muscle, liver and small intestine were observed before and after trauma. The hemodynamic changes were monitored and the survival time was recorded. The results showed that the plasma endothelin concentration increased rapidly after traumatic shock, which was significantly higher than pre-injury level, and reached the level of 5 times pre-injury at 7h after resuscitation. The indexes of arterial blood gas and tissue oxygen partial pressure after shock were higher than those before injury Significant differences, decompensated acidosis after shock, liver and small intestine partial pressure of oxygen than skeletal muscle more significant. It is suggested that the plasma endothelin is significantly increased after traumatic shock, which is important in maintaining blood pressure in the early stage. However, it may be an important cause of death in the late stage of shock. The irreversible reduction of oxygen partial pressure in internal organs may be difficult to recover in the later stage of shock. The key factor.