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从蓮子心中提取出的莲心碱結晶,有短暫的降压作用。改变成季銨盐,就出現強而持久的降压作用。O-甲基-蓮心碱硫酸甲酯季銨盐对迷走神經节較对頸上交感神經节的阻滞作用为強而持久,但迷走神經在降压作用中不起主要作用。脊猫試驗与狗头交叉循环証明其降压机制主要是外周作用,而非中枢作用。 O-甲基-蓮心碱溴甲烷季銨盐对腎型高血压狗也有降压效能。莲心碱的季銨盐与箭毒块茎碱的化学結构不同,缺少一个氧醚鍵。因此莲心碱是一种新型的生物碱,深入研究其化学結构与疗效的关系是很有意义的。
Lotus from heart lotus heart extract, a brief antihypertensive effect. Change into quaternary ammonium salt, there is a strong and lasting antihypertensive effect. O-methyl-linalyl chloride methyl ester quaternary ammonium salt on the vagus ganglia compared with the role of the superior cervical sympathetic ganglia strong and long-lasting, but the vagus nerve can not play a major role in the role of antihypertensive. Ridge cat test and dog head cross-cycle prove that its antihypertensive mechanism is mainly peripheral rather than central role. O-Methyl-Lotusine bromide Methyl bromide also has antihypertensive effect on renal hypertensive dogs. The quaternary ammonium salt of linaxine differs from the chemical structure of the arrowhead tuber base in that it lacks an oxyether bond. Therefore, liexin is a new type of alkaloids, in-depth study of the relationship between the chemical structure and efficacy is of great significance.