多发性硬化(MS)的病因学研究发现,该病与病毒感染相关。Koprowski等首先报告MS病人存在嗜人T淋巴细胞Ⅰ型病毒(Human T-cell lymphotropic virustype-1,HTLV-1)抗体,并经原位杂交方法检测到病毒序列,提示该病毒可能造成MS。但是,Hauser等及Karpas等使用相同方法,其结果却为阴性。然而Ohta等使用蛋白印迹法(Western blot,WB)检测日本的MS Etiology studies of multiple sclerosis (MS) found that the disease was associated with viral infection. Koprowski et al first reported the presence of human T-cell lymphotropic virustype-1 (HTLV-1) antibody in MS patients and detected the virus sequence by in situ hybridization, suggesting that the virus may cause MS. However, Hauser et al. And Karpas et al. Used the same method, but the result was negative. However, Ohta et al. Used Western blot (WB) to detect MS in Japan