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报道OF-3对小鼠的急性毒性实验、对大鼠及犬的长期毒性实验结果。小鼠口服LD50为3.34g/kg;大鼠90d口服剂量分别为0.142、0.112、0.078g/kg,除给药组体重增长缓慢外,其余未出现中毒症状;犬90div剂量0.12~0.03g/kg,该药大剂量对犬的肾脏有轻度损害,对骨髓造血功能有轻度抑制作用。
Reported that OF-3 acute toxicity test in mice, rats and dogs long-term toxicity test results. Mice oral LD50 3.34g / kg; 90d oral dose rats were 0.142,0.112,0.078g / kg, except for the slow increase in body weight gain, the rest did not appear toxic symptoms; dog 90div dose 0.12 ~ 0.03g / kg, the medicine large dose of mild damage to the kidneys of the kidney, hematopoietic function of the bone marrow has a slight inhibitory effect.