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研究对象为12例充血性心衰病人,其中NYHAⅡ级6例,Ⅲ级3例,Ⅳ级3例。研究前24小时内停用除洋地黄以外的一切药物。所有病人在休息30分钟后,口服尼伐地平(nilvadipine,NIL)6mg,给药前及给药后15、30和60分钟分别测定有关血流动力学参数。结果给药30～60分钟时,血流动力学效应达峰值。给药30分钟后,收缩压、舒张压、肺动脉收缩压、肺动脉舒张压、肺楔压、前臂血管阻力和体循环血管阻力分别较给药前降低11.7±2.9%(p<0.01)、12.8±3.4%(p<0.01)、9.2土3.9%(p<0.05)、21.7±
The study included 12 patients with congestive heart failure, including 6 NYHA class Ⅱ, 3 Ⅲ grade and 3 Ⅳ grade. Within 24 hours of the study, all medications except digitalis were discontinued. All patients received 6 mg of nilvadipine (NIL) orally 30 minutes after the rest, and the hemodynamic parameters were measured before administration and at 15, 30 and 60 minutes after the administration. The results of administration of 30 to 60 minutes, the hemodynamic effects of the peak. Systolic pressure, diastolic pressure, pulmonary artery systolic pressure, pulmonary artery diastolic pressure, pulmonary wedge pressure, forearm vascular resistance and systemic vascular resistance decreased by 11.7 ± 2.9% (p <0.01) and 12.8 ± 3.4 % (p <0.01), 9.2 soil 3.9% (p <0.05), 21.7 ±