河南省林县为食管癌高发区,发病率之高居世界之冠,它严重地威胁着人民健康。要预防食管癌,研究食管癌病因是十分重要的。关于食管癌的病因,国外强调饮酒、吸烟、热食、亚(?)胺、微量元素缺乏、营养不足和遗传因素的作用。关于霉菌在食管癌病因学中的作用,仅南非有几篇研究粮食中霉菌毒素的报道。自从1974年我们报道了用自然发霉食物诱发大鼠食管癌 Lin County in Henan Province is a high-risk area of ​​esophageal cancer. The incidence rate is highest in the world. It seriously threatens people’s health. To prevent esophageal cancer, it is important to study the cause of esophageal cancer. With regard to the etiology of esophageal cancer, foreign countries have emphasized the role of drinking, smoking, hot foods, sub-amines, lack of trace elements, nutritional deficiencies, and genetic factors. With regard to the role of mold in the etiology of esophageal cancer, only South Africa has reported several studies on mycotoxins in food. Since 1974 we have reported the use of natural moldy foods to induce esophageal cancer in rats