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目的 观察胶质细胞源性神经营养因子 (GDNF)在成年大鼠背根节中的分布。 方法 用 GDNF多克隆抗体免疫组织化学 ABC法及图像分析方法。 结果 GDNF免疫反应主要存在于背根节的小神经细胞中 ,背根节的大神经细胞呈弱阳性反应 ,与背根节相连的感觉神经纤维呈免疫反应性。 结论 GDNF在背根节感觉神经元和神经纤维中有一定量的分布。
Objective To observe the distribution of glial cell line-derived neurotrophic factor (GDNF) in dorsal root ganglia of adult rats. Methods GDNF polyclonal antibody immunohistochemistry ABC method and image analysis. Results The GDNF immunoreactivity mainly existed in the small nerve cells of dorsal root ganglion. The large nerve cells of dorsal root ganglion showed a weak positive reaction. The sensory nerve fibers connected with dorsal root ganglion were immunoreactive. Conclusion GDNF has some distribution in sensory neurons and nerve fibers in dorsal root ganglion.