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目的总结婴幼儿孢子丝菌病的临床特征、病理特点和治疗效果,提高临床医生对本病的认识,减少误诊。方法对7年间经真菌培养确诊的20例婴幼儿孢子丝菌病进行回顾分析,并与文献报告相比较。结果本组病例发病部位均为面部。皮损表现为炎性肉芽肿或结痂渗出性斑块。其中固定型15例(75.00%),淋巴管型5例(25.00%)。主要病理类型为非特异性炎性肉芽肿改变。20例患儿应用特比萘芬7.5~10mg/(kg·d),连续服用3个月后,均治愈,且无不良反应。结论婴幼儿孢子丝菌病并非少见,口服特比萘芬7.5~10mg/(kg·d)安全有效,耐受性好。
Objective To summarize the clinical features, pathological features and therapeutic effects of sporotrichosis in infants and young children, and to improve clinicians’ understanding of the disease and reduce misdiagnosis. Methods A retrospective analysis of 20 cases of sporotrichosis confirmed by fungal culture in 7 years was performed and compared with the literature. Results The incidence of this group of patients are facial. Skin lesions showed inflammatory granuloma or scab exudative plaque. Among them, 15 were fixed type (75.00%) and 5 were lymphatic type (25.00%). The main pathological type of non-specific inflammatory granuloma change. Twenty patients were treated with terbinafine 7.5 ~ 10mg / (kg · d), after 3 consecutive months of treatment, were cured, and no adverse reactions. Conclusion Infantile sporotrichosis is not uncommon. Terbinafine is safe and effective with 7.5 ~ 10 mg / (kg · d) orally.