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目的探讨舒张功能不良性心衰患者应用美托洛尔后心脏自主神经功能的变化。方法对照组常规抗心衰治疗,治疗组在常规抗心衰治疗的基础上加服美托洛尔,从12.5mg/d开始,缓慢增加剂量至25～50mg/d,治疗前和治疗3个月后分别进行心率变异性(HRV)分析。结果与对照组比较,治疗组治疗3个月后HRV指标SDNN、SDANN、rMSSD、PNN50均明显提高(P<0.01),且心功能改善明显优于对照组(P<0.05)。结论在常规治疗的基础上,加用美托洛尔治疗舒张功能不良性心衰,可改善心脏自主神经调节功能,可提高HRV,增强疗效。
Objective To investigate the changes of cardiac autonomic nerve function after metoprolol in patients with diastolic dysfunction heart failure. Methods The control group was treated with conventional anti-heart failure. The treatment group was given metoprolol on the basis of routine anti-heart failure treatment, starting from 12.5 mg / d, slowly increasing the dosage to 25-50 mg / d, before treatment and 3 Month after heart rate variability (HRV) analysis. Results Compared with the control group, the HRV indexes of SDNN, SDANN, rMSSD and PNN50 in the treatment group were significantly increased (P <0.01) after 3 months of treatment, and the improvement of cardiac function was significantly better than that of the control group (P <0.05). Conclusion On the basis of routine treatment, adding metoprolol to treat diastolic dysfunction can improve cardiac autonomic nervous system function, improve HRV and enhance the curative effect.