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缺氧代谢是恶性肿瘤重要的代谢特征之一。肿瘤微环境的缺氧代谢调控参与多项肿瘤恶性进程,如肿瘤周围血管形成、细胞周期和能量代谢等。新近研究发现,非编码小RNA(microRNA)通过转录后调节作用,在肿瘤的缺氧代谢中发挥着至关重要的作用。其中,最为重要的缺氧相关microRNA为microRNA-210(miR-210)。miR-210的诱导上调是多种恶性肿瘤组织在缺氧状态下的共同特征,其参与肿瘤细胞周期、线粒体氧化代谢、DNA修复等多方面的调控,其高水平表达能够监测肿瘤患者复发以及预后。因此,靶向抑制miR-210可能会抑制多项肿瘤恶性进程,为肿瘤靶向治疗提供新的思路。本文对miR-210在肿瘤微环境及肿瘤恶性进程中的作用作一综述。
Hypoxia metabolism is one of the important metabolic features of malignant tumors. Hypoxia metabolism regulation of tumor microenvironment is involved in many malignant processes, such as the formation of tumor surrounding blood vessels, cell cycle and energy metabolism. Recent studies have found that non-coding microRNAs (miRNAs) play a crucial role in the hypoxia metabolism of tumor through post-transcriptional regulation. Among them, the most important hypoxia related microRNA is microRNA-210 (miR-210). Up-regulation of miR-210 is a common feature of many malignant tumors in hypoxia. It is involved in the regulation of tumor cell cycle, mitochondrial oxidative metabolism and DNA repair. Its high level of expression can monitor tumor recurrence and prognosis . Therefore, the targeted inhibition of miR-210 may inhibit a number of malignant tumor progression and provide a new idea for tumor targeted therapy. This article reviews the role of miR-210 in tumor microenvironment and tumor malignancy.