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FAB形态学分类在1976年报导后,许多中心复查了他们的急性淋巴细胞白血病(ALL)病例,其结果指出有L_2形态学的病例预后不良,有L_3形态学表现的病例相当罕见,但病情严重。本文作者研究了皇家维多利亚医院或纽卡斯尔综合医院中,1972～1980年间所见全部儿童ALL病例,检查是否能证实形态学亚型和预后之间有明显的联系。对89例ALL儿童原先的骨髓涂片作了检查。全部病例都接受过联合化疗和中枢神经系统预防。这些儿童在诊断后被随访1～9年,或死亡,或复发。2人分别
After the morphological classification of FAB was reported in 1976, many centers reviewed their cases of acute lymphoblastic leukemia (ALL). The results indicated that patients with L2 morphology had a poor prognosis. Cases with L3 morphological findings were rare but severely affected. . The authors studied all cases of childhood ALL seen at Royal Victoria Hospital or Newcastle General Hospital between 1972 and 1980. Whether the examination can confirm a clear link between the morphological subtypes and prognosis. The original bone marrow smears of 89 children with ALL were examined. All patients received combination chemotherapy and central nervous system prevention. These children were followed up for 1 to 9 years after diagnosis, or died or relapsed. Two people were separated