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比格犬作为实验动物在生物学、医学和毒理学的科学研究中具有重要作用.其个体差异小,实验数据较准确,成为国际上公认的较为理想的实验动物;且国内外有关药物安全评价试验也作出规定,应取用比格犬作为安全评价试验的动物.一般试验用的比格犬必须进行有关犬的传染病微生物学监测,达标后方能进行试验.有关比格犬的自发性病变,早在1974年国外已有报导,至1990年Morishuima等则较为详尽报导了在安全评价试验中比较大的多种自发性病变.国内尚未见有关这方面的报导.本实验对46只比格大(10～12月龄),进行一般临床表现、血液生化、尿、心电图等检查,并随机选用18只大进行组织病理学观察.实验结果是部分大的肝功能谷雨转氨酶和谷草转氨酶偏高,其余血液生化、尿、心电图检查未见异常.肝、肺、肾和大脑等重要脏器有自发性病变;肺的间质性肺炎和大脑的室管膜炎及血管围管性浸润发生率较高,部分肝细胞和肾小管上皮细胞呈现浊肿或空泡变等.以上结果提示对实验动物宜加强饲养
Beagle dog, as an experimental animal, plays an important role in the scientific research of biology, medicine and toxicology.Its small individual difference and more accurate experimental data have become internationally recognized as ideal experimental animals, and domestic and international researches on drug safety evaluation The test is also made, Beagle dogs should be taken as a safety evaluation test animals. Beagle dogs used in general trials must be microbiological surveillance of infectious diseases in dogs, can only be tested after the test. Beagle dogs with spontaneous lesions , As early as 1974 abroad has been reported by Morishuima et al in 1990 reported in more detail in the safety evaluation test of a large number of spontaneous lesions have not yet been reported in this regard in this study of 46 BIG Large (10 to 12 months old), general clinical manifestations, blood biochemistry, urine, electrocardiogram and other tests, and were randomly selected 18 large histopathological observations.The experimental results are part of the large liver function of glutamic-pyruvic transaminase and aspartate aminotransferase , The other blood biochemistry, urine, ECG abnormalities were not seen.Liver, lung, kidney and brain and other important organs have spontaneous lesions; pulmonary interstitial pneumonia and brain The incidence of meningitis and vascular tube infiltration higher, some hepatocytes and tubular epithelial cells showed turbidity or vacuolar change, etc. These results suggest that the experimental animals should be strengthened feeding