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目的探讨喉癌、下咽癌多原发癌(multiple primary cancers,MPC)患者的临床特点。方法对29例喉癌、下咽癌MPC患者临床资料进行回顾性分析。结果本组病例中喉癌MPC以肺癌(20.7%,6/29),下咽癌MPC以食道癌(24.1%,7/29)为最多见。本组MPC病理类型以鳞癌(占75.9%)最多见,有放、化疗史患者较易发生MPC(62.1%,18/29),有烟、酒嗜好的患者较易发生MPC(58.6%,17/29)。本组总的3年、5年累积生存率分别为37.9%、24.1%。其中积极治疗组3年生存率达50.0%,放弃治疗组3年生存率为0,生存率差异有统计学意义(P=0.0253)。结论喉癌MPC以肺癌最多见,下咽癌MPC以食道癌最多见。有放、化疗史患者较易发生MPC。有烟酒嗜好的患者较易发生MPC。细致的随访和复查、早期明确诊断和积极有效地治疗可以提高MPC患者生存率。
Objective To investigate the clinical features of multiple primary cancers (MPC) in laryngeal and hypopharyngeal cancer patients. Methods The clinical data of 29 patients with laryngeal carcinoma and hypopharyngeal carcinoma were retrospectively analyzed. Results The MPC of laryngeal carcinoma was the most common in this group of patients with lung cancer (20.7%, 6/29) and hypopharyngeal cancer (MPC) with esophageal cancer (24.1%, 7/29). MPC (62.1%, 18/29) were more likely to occur in patients with squamous cell carcinoma (75.9%) than those with MPC (58.6%, P < 17/29). The total 3-year, 5-year cumulative survival rates were 37.9%, 24.1%. Among them, the 3-year survival rate of active treatment group reached 50.0%, and the 3-year survival rate of abandoned treatment group was 0, the difference of survival rate was statistically significant (P = 0.0253). Conclusion The most common form of laryngeal carcinoma is MPC, while hypopharyngeal cancer MPC is the most common form of esophageal cancer. A place, the history of chemotherapy more prone to MPC. Patients with alcohol and tobacco preferences are more prone to MPC. Meticulous follow-up and review, early diagnosis and positive and effective treatment can improve the survival rate of MPC patients.